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How does corona virus cause damage to the heart? This claim made in research

Research on SARS-CoV-2: Scientists have identified the mechanism behind how the SARS-CoV-2 virus damages heart tissue. The study says that people with Kovid-19 have a significant risk of swelling of the heart muscle, abnormal heart beat, blood clots, stroke, heart attack and heart failure for at least one year after infection. There is more risk.

Scientists at the University of Maryland, Baltimore in the US have used a drug to reverse the toxic effects of the SARS-Cov-2 virus protein on the heart. Jay Han, senior author of the related study report, said, ‘Our research shows that the SARS-Cov-2 protein can cause major damage to specific tissues in the body. As is the case with other viruses like HIV and Zika.

In this case, the report of the study done on the heart cells of fruit flies and mice has been published in Nature Communications Biology. Although scientists around the world rapidly develop vaccines and drugs to reduce the severity of the COVID-19 disease, the study says these treatments do not protect the heart or other organs from the damage that a mild infection would cause. Might as well. Last year, Han and his team identified the most toxic SARS-Cov-2 protein in a study using fruit flies and human cells. According to the study, they found that the drug ‘Salinexor’ reduced the toxicity of one of these proteins, but not the other, known as SSC6.

What the study found in the heart of the fruit fly

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In their latest study, they found that Nsp6 turned out to be the most toxic SARS-Cov-2 protein in fruit fly hearts. According to this study, the researchers found that the NSP6 protein hijacked the fruit fly’s cells in its heart to trigger the glycolysis process, which enables the cells to burn the sugar glucose for energy.

Normally, heart cells use fatty acids as an energy source, but during heart failure sugars are metabolized as these cells attempt to repair damaged tissue. The researchers also found that the NSP6 protein caused damage by disrupting the mitochondria, the “powerhouses” of cells that produce energy from sugar metabolism.

affect the cell machinery of the animal, SARS-CoV-2

The team then used the drug 2-deoxy-D-glucose (2DG) to disrupt sugar metabolism in the heart cells of fruit flies and mice. The study said that the drug reduced damage to the heart and mitochondria caused by the NSP6 protein. Han said, ‘We know that some viruses affect the cell machinery of an infected animal to alter its metabolism to defeat the cell’s energy source, so we think that SARS-CoV-2 does something similar. Is. Viruses can also use by-products of sugar metabolism as building blocks to produce more viruses.

What the researchers said on 2DG

‘Therefore, we can predict that this drug that alters metabolism in the heart prior to infection will prove fatal for the virus,’ Han said. It is used in. The study said that although 2DG is not approved by the US Food and Drug Administration for the treatment of the disease, the drug is undergoing medical trials for the treatment of Kovid-19 in India.

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